

If I remember correctly, the book opens with a prologue describing the business/finance hype in biotech, where a bunch of startups are raising funds and racing to get rich revolutionizing how to commercialize the exciting cutting edge in biological science in that era. It has nothing to do with the plot and the characters of the book, except that it establishes the tone, the background, and the incentives at play.
Even with anaerobic metabolism, the process produces lactate and pyruvate as a byproduct that the body needs to clear that out, which generally involves oxygen consumption. So the energy expenditure might spike in that moment without a corresponding spike in oxygen in that moment, but the amount over time should increase to where the overall amount should still correlate with total calori expenditure.