um… did my bio get deleted?

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Joined 2 years ago
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Cake day: June 13th, 2023

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  • Useful info, thank you. Once in a great while I have outages of a week or a little more, usually because something breaks when I just can’t rally the resources to fix it right away. Ideally this would never happen on infrastructure used to run an instance, but my hope is that various fedi platforms will be resilient to downtime on the order of 7-14 days before they entirely give up. I think it would be helpful to small and/or broke instance operators, and I would like a fedi with lots of little instances. :)


  • I don’t have examples offhand, but recently did a bit of reading at the behest of a friend whose cats had fleas, and recently developed pesticides were found to be active at levels of just a few nanograms per flea. Many of the newer insecticides are active to this degree, or close to it. Industry started designing pesticides using the principles of Rational Drug Design and quickly came up with a bunch of fantastically lethal (to the target, namely, insects) chemicals which are now being sprayed all over the environment.

    Related: if you’ve ever happened to notice that more recently developed medications often require a lower dose, in milligrams, than older ones in the same class - that isn’t by accident. There are a number of principles that can be used to increase the potency of a candidate bio-active chemical, pesticides included.